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Annual Review of Pharmacology and Toxicology

Volume 40, 2000

Targets of Drug Action

Abstract

This article considers early work from the author’s laboratory on muscarinic receptor specificity, subtypes, and conformational variability, with the use of nuclear magnetic resonance in pharmacology and the conformational variants of dihydrofolate reductase and general questions of receptors. It also considers some current approaches to drug development and receptor function, particularly as influenced by increasing knowledge of three-dimensional structure of receptors.

Keyword(s): acetylcholine, Autobiography, botulinum, carbonic anhydrase, conformation, DHFR, drug design, muscarinic, NMR, receptors
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2000-04-01
2024-05-10
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